July 28, 2017

Applying Shark Science to Human Health

Viewers of the Discovery Channel’s highly anticipated Shark Week may not know about the different role sharks play aside from teeth-thrashing and jaw-clamping they see on television.
By Jennifer Barrett

5. Fibrosis
Australian researchers have developed a drug that mimics part of a shark’s immune system to treat idiopathic pulmonary fibrosis (IPF).5 The drug, called AD-114, was inspired by an antibody found in shark blood, specifically in the Wobbegong shark. AD-114 was designated an orphan drug by the FDA and is expected to start human trials in 2018.

Other laboratory tests have indicated the drug’s potential to treat other forms of fibrosis, such as liver disease and age-related eyesight degeneration.

This article originally appeared on pharmacytimes.com.

 
References:
  1. FDA approves Integra Omnigraft Dermal Regeneration Matrix to treat diabetic foot ulcers [news release]. FDA’s website. https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm480564.htm. Accessed July 24, 2017.
  2. Marra NJ, Richards VP, Early A, et al. Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy. BMC Genomics 2017; 18 (1). doi: 10.1186/s12864-016-3411-x
  3. Mann EE, Manna D, Mettetal MR, et al. Surface micropattern limits bacterial contamination. Antimicrobiral Resistance and Infection Control. 2014; 3:28. Doi: 10.1186/2047-2994-3-28
  4. Exciting breakthrough in antibody research [news release]. Lundbeck’s website. http://www.lundbeck.com/global/about-us/features/2017/exciting-breakthrough-in-antibody-research. Accessed July 24, 2017.
  5. World first trial of shark inspired drug [news release]. La trobe’s website. http://www.latrobe.edu.au/news/articles/2017/release/world-first-trial-of-shark-inspired-drug. Accessed July 24, 2017.


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